Neuronal input-output computation and mechanisms of cognition in health and disease


Bohmbach, K., Masala, N., Schönhense, E.M., Hill, K., Haubrich, A.N., Zimmer, A., Opitz, T., Beck, H., Henneberger, C. (2022) An astrocytic signaling loop for frequency-dependent control of dendritic integration 2 and spatial learning. Nature Communications, in press.

Masala, N., Pofahl, M., Haubrich A.N., Nikbakht, N., Bohmbach, K., Henneberger, C., Golcuk, K., Kelly, T., Beck, H. (2022) Degraded dendritic input feature detection underlies spatial memory deficits in epilepsy. Brain doi: 10.1093/brain/awac455 .

Royero P., Quatraccioni A., Früngel, R., Bast, A., Ulas, T., Beyer, M., Schultze, J.L., Oberlaender, M., Becker A., Schoch S., Beck, H.(2022) Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase. Cell Reports, 41, 111757. 

Goldenberg, A.M., Schmidt, S., Mitelman, R., Levy, D.R., Katz, Y., Yizhar, O., Beck, H., Lampl I. (2022) Localized chemogenetic silencing of inhibitory neurons: a novel mouse model of focal cortical epileptic activity. Cerebral Cortex, 1-19, .

Müller-Komorowska D., Parabucki, A., Elyasaf, G., Katz, Y., Beck, H., Lampl, I. (2022) A novel theoretical framework for simultaneous measurement of excitatory and inhibitory conductances. PLOS Comp. Biol.,


Schoch, S., Quatraccioni, A., Robens, B. K., Maresch, R., van Loo, K., Cases-Cunillera, S., Kelly, T., Opitz, T., Borger, V., Dietrich, D., Pitsch, J., Beck, H., & Becker, A. J. (2021). Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy. J. Neuroscience:the official journal of the Society for Neuroscience41(39), 8111–8125.

Pofahl, M., Nikbakht, N., Haubrich, A. N., Nguyen, T., Masala, N., Distler, F., Braganza, O., Macke, J. H., Ewell, L. A., Golcuk, K., & Beck, H. (2021). Synchronous activity patterns in the dentate gyrus during immobility. eLife10, e65786.

Schmidt, S., Pothmann, L., Müller-Komorowska, D., Opitz, T., Soares da Silva, P., & Beck, H. (2021). Complex effects of eslicarbazepine on inhibitory micro networks in chronic experimental epilepsy. Epilepsia62(2), 542–556.


Müller-Komorowska, D., Opitz, T., Elzoheiry, S., Schweizer, M., Ambrad Giovannetti, E., & Beck, H. (2020). Nonspecific Expression in Limited Excitatory Cell Populations in Interneuron-Targeting Cre-driver Lines Can Have Large Functional Effects. Frontiers in neural circuits14, 16.

Braganza, O., Mueller-Komorowska, D., Kelly, T., & Beck, H. (2020). Quantitative properties of a feedback circuit predict frequency-dependent pattern separation. eLife, 9, e53148.


Pothmann, L., Klos, C., Braganza, O., Schmidt, S., Horno, O., Memmesheimer, R. M., & Beck, H. (2019). Altered Dynamics of Canonical Feedback Inhibition Predicts Increased Burst Transmission in Chronic Epilepsy. J. Neuroscience: the official journal of the Society for Neuroscience39(45), 8998–9012.

Jeub, M., Taha, O., Opitz, T., Racz, I., Pitsch, J., Becker, A., & Beck, H. (2019). Partial sciatic nerve ligation leads to an upregulation of Ni2+-resistant T-type Ca2+ currents in capsaicin-responsive nociceptive dorsal root ganglion neurons. Journal of pain research12, 635–647.


Bernal Sierra, Y. A., Rost, B. R., Pofahl, M., Fernandes, A. M., Kopton, R. A., Moser, S., Holtkamp, D., Masala, N., Beed, P., Tukker, J. J., Oldani, S., Bönigk, W., Kohl, P., Baier, H., Schneider-Warme, F., Hegemann, P., Beck, H., Seifert, R., & Schmitz, D. (2018). Potassium channel-based optogenetic silencing. Nature communications9(1), 4611.

Sheng, C., Jungverdorben, J., Wiethoff, H., Lin, Q., Flitsch, L. J., Eckert, D., Hebisch, M., Fischer, J., Kesavan, J., Weykopf, B., Schneider, L., Holtkamp, D., Beck, H., Till, A., Wüllner, U., Ziller, M. J., Wagner, W., Peitz, M., & Brüstle, O. (2018). A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nature communications, 9(1), 4047.

Holtkamp, D., Opitz, T., Hebeisen, S., Soares-da-Silva, P., & Beck, H. (2018). Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells. Epilepsia59(8), 1492–1506.

Beckonert, N. M., Opitz, T., Pitsch, J., da Silva, P., Beck, H. (2018) Polyamine modulation of anticonvulsant drug response: A potential mechanism contributing to pharmacoresistance in chronic epilepsy. J. Neuroscience. 13 June 2018, 38 (24) 5596-5605 (PubMed)

Braganza, O., Beck, H. (2018) The circuit motif as conceptual tool for multilevel neuroscience. Trends Neurosci. 41: 128-136. (PubMed)

Becker, A.J., Beck, H. (2018) New developments in understanding focal cortical malformations. Curr. Opin. Neurobiol. 31: 151-155. (pdf)


Taha, O., Opitz, T., Müller, M., Pitsch, J., Becker, A., Evert, B.O., Beck, H., Jeub, M. (2017) Neuropathic pain in experimental autoimmune neuritis is associated with altered electrophysiological properties of nociceptive DRG neurons. Exp. Neurol.,297: 25-35. (PubMed)

Holtkamp, D., Opitz, T., Niespodziany, I., Wolff, C., Beck, H. (2017) Activity of the anticonvulsant lacosamide in experimental and human epilepsy via selective effects on slow Na+ channel inactivation. Epilepsia, 58: 27-41. (PubMed)

Kelly, T., Beck, H. (2017) Functional properties of granule cells with hilar basal dendrites in the epileptic dentate gyrus. Epilepsia, 58: 160-171. (PubMed)


Pitkänen, A., Löscher, W., Vezzani, A., Becker, A.J., Simonato, M., Lukasiuk, K., Gröhn, O., Bankstahl, J.P., Friedman, A., Aronica, E., Gorter, J.A., Ravizza, T., Sisodiya, S.M., Kokaia, M., Beck, H. (2016) Advances in the development of biomarkers for epilepsy. Lancet Neurol., 15: 843-856. (pdf)

Pabst, M., Braganza, O., Dannenberg, H., Hu, W., Pothmann, L., Rosen, J., Mody, I., van Loo, K., Deisseroth, K., Becker, A.J., Schoch, S., Beck, H. (2016) Astrocyte intermediaries of septal cholinergic modulation in the hippocampus. Neuron, 90: 853-865. (PubMed) Featured in: Science Signalling, Editors Choice. (2016) Astrocytes help make memories. Sci. Signal., 9: ec126. (pdf)


Royeck, M., Kelly, T., Opitz, T., Otte, D.M., Rennhack, A., Woitecki, A., Pitsch, J., Becker, A., Schoch, S., Kaupp, U.B., Yaari, Y., Zimmer, A., Beck, H. (2015) Downregulation of spermine augments dendritic persistent sodium currents and synaptic integration after status epilepticus. J. Neurosci., 35: 15240-15253. (PubMed)

Van Loo, K.M.J., Schaub, C., Pitsch, J., Kulbida, R., Opitz, T., Ekstein, D., Dalal, A., Urbach, H., Beck, H., Yaari, Y., Schoch, S., Becker, A.J. (2015) Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nature Comm., 6: 8688. (pdf)

Kabanova, A., Pabst, M., Lorkowski, M., Braganza, O., Boehlen, A., Nikbakht, N., Pothmann, L., Vaswani, A.R., Musgrove, R., Di Monte, D.A., Sauvage, M., Beck, H., Blaess, S. (2015) Function and developmental origin of a mesocortical inhibitory circuit. Nat. Neurosci., 18: 872-882. (PubMed)

Dannenberg, H., Pabst, M., Braganza, O., Schoch, S., Niediek, J., Bayraktar, M., Mormann, F., Beck, H. (2015) Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks. J. Neurosci., 35: 8394-8410. (PubMed)

Lennarz, S., Alich, T.C., Kelly, T., Blind, M., Beck, H., Mayer, G. (2015) Selective aptamer-based control of intraneuronal signaling. Angew. Chemie, 54: 5369-5373. (PubMed)

Doeser, A., Dickhof, G., Reitze, M., Uebachs, M., Schaub, C., Pires, N.M., Bonifácio M.J., Soares da Silva, P., Beck, H. (2015) Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug. Brain, 138: 371-387. (pdf)


Hedrich, U.B., Liautard, C., Kirschenbaum, D., Pofahl, M., Lavigne, J., Liu, Y., Theiss, S., Slotta, J., Escayg, A., Dihné, M., Beck, H., Mantegazza, M., Lerche, H. (2014) Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human NaV1.1 mutation. J. Neurosci., 34: 14874-14889. (PubMed)

Thome, C., Kelly, T., Yanez, A., Schultz, C., Engelhardt, M., Campbridge, S.B., Both, M., Draguhn, A., Beck, H., Egorov, A.V. (2014) Axon-carrying dendrites convey privileged synaptic input in hippocampal neurons. Neuron, 83: 1418-1430. (PubMed)

Pothmann, L., Müller, C., Averkin, R.G., Bellistri, E., Miklitz, C., Uebachs, M., Remy, S., Menendez de la Prida, L., Beck, H. (2014) Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs. J. Neurosci., 34: 9720-9735. (PubMed)

Doeser, A., Soares-da-Silva, P., Beck, H., Uebachs, M. (2014) The effects of eslicarbazepine on persistent Na⁺ current and the role of the Na⁺ channel β subunits. Epilepsy Res., 108: 202-211. (PubMed)

Pradier, B., Jeub, M., Markert, A., Mauer, D., Tolksdorf, K., Van de Putte, T., Seuntjens, E., Gailus-Durner, V., Fuchs, H., Jeub, M., Hrabě de Angelis, M., Huylebroeck, D., Beck, H., Zimmer, A., Rácz, I. (2014) Smad-interacting protein 1 affects acute and tonic, but not chronic pain.  Eur. J. Pain, 18: 249-257. (PubMed)


Klatte, K., Kirschstein, T., Otte, D., Pothmann, L., Müller, L., Tokay, T., Kober, M., Uebachs, M., Zimmer, A., Beck, H. (2013) Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy. J. Neurosci., 33: 13066-13080. (PubMed)

Alvarez-Baron, E., Michel, K., Mittelstaedt, T., Opitz, T., Schmitz, F., Beck, H., Dietrich, D., Becker, A.J., Schoch, S. (2013) RIM3γ and RIM4γ are key regulators of neuronal arborization. J. Neurosci., 33: 824-839. (PubMed)


Uebachs, M., Albus, C., Opitz, T., Isom, L., Niespodziany, I., Wolff, C., Beck, H. (2012) Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents. Epilepsia, 53: 1959-1967. (PubMed)

Pitsch, J., Opitz, T., Borm, V., Woitecki, A., Staniek, M., Beck, H., Becker, A.J., Schoch, S. (2012) The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus. J. Neurosci., 32: 12384-12395. (PubMed)

Müller, C., Beck, H., Coulter, D., Remy, S. (2012) Inhibitory control of linear and supralinear dendritic excitation in CA1 pyramidal neurons. Neuron, 75: 851-864. (PubMed)

Surges, R., Kukley, M., Brewster, A., Rüschenschmidt, C., Schramm, J., Baram, T.Z., Beck, H., Dietrich, D. (2012) Hyperpolarization-activated cation current Iof dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy. Biochem. Biophys. Res. Commun., 420: 156-160. (pdf)

Van Loo, K.M., Schaub, C., Pernhorst, K., Yaari, Y., Beck, H., Schoch, S., Becker, A.J. (2012) Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J. Biol. Chem., 287: 15489-15501. (PubMed)

Beck, H., Yaari. Y. (2012) Antiepileptogenesis, Plasticity of AED Targets, Drug Resistance, and Targeting the Immature Brain. In: Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition. Eds. Noebels, J.L., Avoli, M., Rogawski, M.A., Olsen, R.W., Delgado-Escueta, A.V. Bethesda: National Center for Biotechnology Information, pp. 1077-1085. (PubMed)


Jeub, M., Emrich, M., Pradier, B., Taha, O., Gailus-Durner, V., Fuchs, H., de Angelis, M.H., Huylebroeck, D., Zimmer, A., Beck, H., Racz, I. (2011) The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. Pain, 152: 2384-2398. (PubMed)

Krueppel, R., Remy, S., Beck, H. (2011) Dendritic integration in hippocampal dentate granule cells. Neuron, 71: 512-528. (PubMed)

Otte, D.M., Sommersberg, B., Kudin, A., Guerrero, C., Albayram, Ö., Filiou, M.D., Frisch, P., Yilmaz, Ö., Drews, E., Turck, C.W., Bilkei-Gorzó, A., Kunz, W.S., Beck, H., Zimmer, A. (2011) N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice. Neuropsychopharmacology, 36: 2233-2243. (PubMed)

Chen, S., Su, H., Yue, C., Remy, S., Royeck, M., Sochivko, D., Opitz, T., Beck, H., Yaari, Y. (2011) An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus. J. Neurophysiol., 105: 117-129. (PubMed)


Barnes, S.J., Opitz, T., Merkens, M., Kelly, T., von der Brelie, C., Krueppel, R., Beck, H. (2010) Stable mossy fiber long-term potentiation requires calcium influx at the granule cell soma, protein synthesis, and microtubule-dependent axonal transport. J. Neurosci., 30: 12996-13004. (PubMed)

Coras, R., Siebzehnrubl, F.A., Pauli, E., Huttner, H.B., Njunting, M., Kobow, K., Villmann, C., Hahnen, E., Neuhuber, W., Weigel, D., Buchfelder, M., Stefan, H., Beck, H., Steindler, D.A., Blümcke, I. (2010) Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. Brain, 133: 3359-3372. (pdf)

Wimmer, V.C., Reid, C.A., Mitchell, S., Richards, K.L., Scaf, B.B., Leaw, B.T., Hill, E.L., Royeck, M., Horstmann, M.-T., Cromer, B.A., Davies, P.J., Xu, R., Lerche, H., Berkovic, S.F., Beck, H., Petrou, S. (2010) Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J. Clin. Invest., 120: 2661-2671. (pdf)

Uebachs, M., Opitz, T., Royeck, M., Dickhof, G., Horstmann, M.-T., Isom, L.L., Beck, H. (2010) Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J. Neurosci., 30: 8489-8501. (PubMed)

Remy, S., Beck, H., Yaari, Y. (2010) Plasticity of voltage-gated ion channels in pyramidal cell dendrites. Curr. Opin. Neurobiol. 20: 503-509. (pdf)


Remy, S., Csicsvari, J., Beck, H. (2009) Activity-dependent control of neuronal output by local and global dendritic spike attenuation. Neuron, 61: 906-916. (PubMed) Comment in ‘Neuron Previews’ by Tiago Branco and Michael Häusser.


Beck, H., Yaari, Y. (2008) Plasticity of intrinsic neuronal properties in CNS disorders. Nat. Rev. Neurosci., 9: 357-369. (PubMed)

Royeck, M., Horstmann, M.-T., Remy, S., Reitze, M., Yaari, Y., Beck, H. (2008) Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. J. Neurophysiol., 100: 2361-2380. (PubMed)

Beck, H., Elger, C.E. (2008) Epilepsy research: a window onto function to and dysfunction of the human brain. Dialogues Clin. Neurosci., 10: 7-15. (PubMed)

Beck, H., Yaari, Y. (2008) Plasticity of intrinsic neuronal properties in CNS disorders. Nat. Rev. Neurosci., 9: 357-369. (PubMed)

Sisodiya, S.M., Beck, H., Löscher, W., Vezzani, A. (2008) Mechanisms of Drug Resistance. In: Epilepsy: A Comprehensive Textbook, Second Edition. Eds. Engel Jr., J., Pedley, T. A. Philadelphia: Lippincott Williams & Wilkins, pp. 1279-1289.

Mathern, G.W., Wilson, C.L., Beck, H. (2008) Hippocampal Sclerosis. In: Epilepsy: A Comprehensive Textbook, Second Edition. Eds. J. Engel, Jr. and T. A. Pedley. Philadelphia: Lippincott Williams & Wilkins, pp. 121-136