Neuronal input-output computation and mechanisms of cognition in health and disease


Eckhardt, M., Hedayati, K.K., Pitsch, J., Lüllmann-Rauch, R., Beck, H., Fewou, S.N., Gieselmann, V. (2007) Sulfatide storage in neurons causes hyperexcitability and axonal degeneration in a mouse model of metachromatic leukodystrophy. J. Neurosci., 27: 9009-9021. (PubMed)

Kirschstein, T., Bauer, M., Müller, L., Rüschenschmidt, C., Reitze, M., Becker, A.J., Schoch, S., Beck, H. (2007) Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J. Neurosci., 27: 7696-7704. (PubMed)

Bender, R.A., Kirschstein, T., Kretz, O., Brewster, A.L., Richichi, C., Rüschenschmidt, C., Shigemoto, R., Beck, H., Frotscher, M., Baram, T.Z. (2007) Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J. Neurosci., 27: 4697-4706. (PubMed)

Schaub, C., Uebachs, M., Beck, H. (2007) Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy. Epilepsia, 48: 1339-1350. (PubMed)

Müller, A., Kukley, M., Uebachs, M., Beck, H., Dietrich, D. (2007) Nanodomains of single Ca2+ channels contribute to action potential repolarization in cortical neurons. J. Neurosci., 27: 483-495. (PubMed)

Beck, H. (2007) Plasticity of antiepileptic drug targets. Epilepsia, 48 (Suppl. 1): 14-18. (PubMed)


Wiese, C., Rolletschek, A., Kania, G., Navarrete-Santos, A., Anisimov, S.V., Steinfarz, B., Tarasov, K.V., Brugh, S.A., Zahanich, I., Rüschenschmidt, C., Beck, H., Blyszczuk, P., Czyz, J., Heubach, J.F., Ravens, U., Horstmann, O., St-Onge, L., Braun, T., Brüstle, O., Boheler, K.R., Wobus, A.M. (2006) Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro. Stem Cells, 24: 2085-2097. (PubMed)

Surges, R., Brewster, A.L., Bender, R.A., Beck, H., Feuerstein, T.J., Baram, T.Z. (2006) Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. Eur. J. Neurosci., 24: 94-104. (PubMed)

Uebachs, M., Schaub, C., Perez-Reyes, E., Beck, H. (2006) T-type Ca2+ channels encode prior neuronal activity as modulated recovery rates. J. Physiol., 571: 519-536. (PubMed)

Rüschenschmidt, C., Chen, J., Becker, A., Riazanski, V., Beck, H. (2006) Functional properties and oxidative modulation of A-type K currents in hippocampal granule cells of control and chronically epileptic rats. Eur. J. Neurosci., 23: 675-685. (PubMed)

von der Brelie, C., Waltereit, R., Zhang, L., Beck, H., Kirschstein, T. (2006) Impaired synaptic plasticity in a rat model of tuberous sclerosis. Eur. J. Neurosci., 23: 686-692. (PubMed)

Remy, S., Beck, H. (2006) Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain, 129: 18-35. (pdf)

Heinemann, U., Kann, O., Remy, S., Beck, H. (2006) Novel mechanisms underlying drug resistance in temporal lobe epilepsy. Adv. Neurol., 97: 85-95. (PubMed)


Yue, C., Remy, S., Su, H., Beck, H., Yaari, Y. (2005) Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. J. Neurosci., 25: 9704-9720. (PubMed)

Zhang, L., Kirschstein, T., Sommersberg, B., Merkens, M., Manahan-Vaughan, D., Elgersma, Y., Beck, H. (2005) Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II. J. Neurosci., 25: 7697-7707. (PubMed)

Müller, A., Kukley, M., Stausberg, P., Beck, H., Müller, W., Dietrich, D. (2005) Endogenous Ca2+ buffer concentration and Ca2+ microdomains in hippocampal neurons. J. Neurosci., 25: 558-565. (PubMed)

Rüschenschmidt, C., Koch, P.G., Brüstle, O., Beck, H. (2005) Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats. Epilepsia, 46 Suppl 5: 174-183. (PubMed)


Remy, C., Remy, S., Beck, H., Swandulla, D., Hans, M. (2004) Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons. Neuropharmacology, 47: 1102-1112. (pdf)

Bernard, C., Anderson, A., Becker, A., Poolos, N.P., Beck, H., Johnston, D. (2004) Acquired dendritic channelopathy in temporal lobe epilepsy. Science, 305: 532-535. (pdf, supplement)

Wernig, M., Benninger, F., Schmandt, T., Rade, M., Tucker, K.L., Büssow, H., Beck, H., Brüstle, O. (2004) Functional integration of embryonic stem cell-derived neurons in vivo. J. Neurosci., 24: 5258-5268. (PubMed)

Kirschstein, T., von der Brelie, C., Steinhäuser, M., Vinçon, A., Beck, H., Dietrich, D. (2004) L-CCG-I activates group III metabotropic glutamate receptors in the hippocampal CA3 region. Neuropharmacology, 47: 157-162. (pdf)


Scheffler, B., Schmandt, T., Schröder, W., Steinfarz, B., Husseini, L., Wellmer, J., Seifert, G., Karram, K., Beck, H., Blümcke, I., Wiestler, O.D., Steinhäuser, C., Brüstle, O. (2003) Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures. Development, 130: 5533-5541. (pdf)

Bender, R.A., Soleymani, S.V., Brewster, A.L., Nguyen, S.T., Beck, H., Mathern, G.W., Baram, T.Z. (2003) Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J. Neurosci., 23: 6826-6836. (PubMed)

Benninger, F., Beck, H., Wernig, M., Tucker, K.L., Brüstle, O., Scheffler, B. (2003) Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures. J. Neurosci., 23: 7075-7083. (PubMed)

Dietrich, D., Kirschstein, T., Kukley, M., Pereverzev, A., von der Brelie, C., Schneider, T., Beck, H. (2003) Functional specialization of presynaptic Cav2.3 Ca2+ channels. Neuron, 39: 483-496. (PubMed)

Remy, S., Urban, B.W., Elger, C.E., Beck, H. (2003) Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats. Eur. J. Neurosci., 17: 2648-2658. (PubMed)

Ellerkmann, R., Remy, S., Chen, J., Sochivko, D., Elger, C.E., Urban, B.W., Becker, A., Beck, H. (2003) Molecular and functional changes in voltage-dependent Na+ channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience, 119: 323-333. (pdf)

Remy, S., Gabriel, S., Urban, B.W., Dietrich, D., Lehmann, T.-N., Elger, C.E., Heinemann, U., Beck, H. (2003) A novel mechanism underlying drug resistance in chronic epilepsy. Ann. Neurol., 53: 469-479. (PubMed)

Sochivko, D., Chen, J., Becker, A., Beck, H. (2003) Blocker-resistant Ca2+ currents in rat CA1 hippocampal pyramidal neurons. Neuroscience, 116: 629-638. (pdf)


Fasen, K., Beck, H., Elger, C.E., Lie, A.A. (2002) Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. J. Neuropathol. Exp. Neurol., 61: 903-913. (pdf)

Wellmer, J., Su, H., Beck, H., Yaari, Y. (2002) Long-lasting modification of intrinsic discharge properties in subicular neurons following status epilepticus. Eur. J. Neurosci.,16: 259-266. (PubMed)

Becker, A.J., Chen, J., Paus, S., Normann, S., Beck, H., Elger, C.E., Wiestler, O.D., Blümcke, I. (2002) Transcriptional profiling in human epilepsy: expression array and single cell real-time qRT-PCR analysis reveal distinct cellular gene regulation. Neuroreport,13: 1327-1333. (PubMed)

Sochivko, D., Pereverzev, A., Smyth, N., Gissel, C., Schneider, T., Beck, H. (2002) The Cav2.3 Ca2+ channel subunit contributes to R-type Ca2+ currents in murine hippocampal and neocortical neurones. J. Physiol., 542: 699-710. (PubMed)

Su, H., Sochivko, D., Becker, A., Chen, J., Jiang, Y., Yaari, Y., Beck, H. (2002) Upregulation of a T-type Ca2+ channel causes a long-lasting modification of neuronal firing mode after status epilepticus. J. Neurosci., 22: 3645-3655. (PubMed)

Kudin, A.P., Kudina, T.A., Seyfried, J., Vielhaber, S., Beck, H., Elger, C.E., Kunz, W.S. (2002) Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus. Eur. J. Neurosci., 15: 1105-1114. (PubMed)

Jeub, M., Beck, H., Siep, E., Rüschenschmidt, C., Speckmann, E.-J., Ebert, U., Potschka, H., Freichel, C., Reissmüller, E., Löscher, W. (2002) Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats. Neuropharmacology, 42: 107-116. (pdf)

Yaari, Y., Beck, H. (2002) “Epileptic neurons” in temporal lobe epilepsy. Brain Pathol., 12: 234-239. (PubMed)


Riazanski, V., Becker, A., Chen, J., Sochivko, D., Lie, A., Wiestler, O.D., Elger, C.E., Beck, H. (2001) Functional and molecular analysis of transient voltage-dependent K+ currents in rat hippocampal granule cells. J. Physiol., 537: 391-406. (PubMed)

Chen, J., Sochivko, D., Beck, H., Marechal, D., Wiestler, O.D., Becker, A.J. (2001) Activity-induced expression of common reference genes in individual CNS neurons. Lab. Invest., 81: 913-916. (PubMed)

Ellerkmann, R.K., Riazanski, V., Elger, C.E., Urban, B.W., Beck, H. (2001) Slow recovery from inactivation regulates the availability of voltage-dependent Na+ channels in hippocampal granule cells, hilar neurons and basket cells. J. Physiol., 532: 385-397. (PubMed)

Grunwald, T., Beck, H., Elger, C.E. (2001) Bausteine des Gedächtnisses: Untersuchungen der menschlichen Hippokampusfunktion in-vivo und in-vitro. Neuroforum, 3: 114-121. (pdf)


Kunz, W.S., Kudin, A.P., Vielhaber, S., Blümcke, I., Zuschratter, W., Schramm, J., Beck, H., Elger, C.E. (2000) Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy. Ann. Neurol., 48: 766-773. (PubMed)

Söhl, G., Güldenagel, M., Beck, H., Teubner, B., Traub, O., Gutiérrez, R., Heinemann, U., Willecke, K. (2000) Expression of connexin genes in hippocampus of kainate-treated and kindled rats under conditions of experimental epilepsy. Brain Res. Mol. Brain Res., 83: 44-51. (PubMed)

Beck, H., Goussakov, I.V., Lie, A., Helmstaedter, C., Elger, C.E. (2000) Synaptic plasticity in the human dentate gyrus. J. Neurosci., 20: 7080-7086. (PubMed)

Goussakov, I.V., Fink, K., Elger, C.E., Beck, H. (2000) Metaplasticity of mossy fiber synaptic transmission involves altered release probability. J. Neurosci., 20: 3434-3441. (PubMed)

Nägerl, U.V., Mody, I., Jeub, M., Lie, A.A., Elger, C.E., Beck, H. (2000) Surviving granule cells of the sclerotic human hippocampus have reduced Ca2+ influx because of a loss of calbindin-D28k in temporal lobe epilepsy. J. Neurosci., 20: 1831-1836. (PubMed)

Blümcke, I., Becker, A.J., Klein, C., Scheiwe, C., Lie, A.A., Beck, H., Waha, A., Friedl, M.G., Kuhn, R., Emson, P., Elger, C., Wiestler, O.D. (2000) Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients. J. Neuropathol. Exp. Neurol., 59: 1-10. (pdf)

Lie, A.A., Becker, A., Behle, K., Beck, H., Malitschek, B., Conn, P.J., Kuhn, R., Nitsch, R., Plaschke, M., Schramm, J., Elger, C.E., Wiestler, O.D., Blümcke, I. (2000) Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann. Neurol., 47: 26-35. (PubMed)

Schumacher, T.B., Beck, H., Steffens, R., Blümcke, I., Schramm, J., Elger, C.E., Steinhäuser, C. (2000) Modulation of calcium channels by group I and group II metabotropic glutamate receptors in dentate gyrus neurons from patients with temporal lobe epilepsy. Epilepsia, 41: 1249-1258. (PubMed)

Elger, C.E., Beck, H. (2000) Anfallserkrankungen. In: Lehrbuch der Pathophysiologie. Eds. Fölsch, U.R., Kochsieck, K., Schmidt, R.F. Berlin, Heidelberg: Springer Verlag, pp. 497-510.


Grunwald, T., Beck, H., Lehnertz, K., Blümcke, I., Pezer, N., Kurthen, M., Fernandez, G., Van Roost, D., Heinze, H.J., Kutas, M., Elger, C.E. (1999) Evidence relating human verbal memory to hippocampal N-methyl-D-aspartate receptorss. Proc. Natl. Acad. Sci. USA, 96: 12085-12089. (PubMed)

Kudin, A., Vielhaber, S., Beck, H., Elger, C.E., Kunz, W.S. (1999) Quantitative investigation of mitochondrial function in single rat hippocampal slices: a novel application of high-resolution respirometry and laser-excited fluorescence spectroscopy. Brain Res. Brain Res. Protoc., 4: 329-334. (PubMed)

Blümcke, I, Beck, H., Lie, A.A., Wiestler, O.D. (1999) Molecular neuropathology of human mesial temporal lobe epilepsy. Epilepsy Res., 36: 205-223. (pdf)

Jeub, M., Lie, A., Blümcke, I., Elger, C.E., Beck, H. (1999) Loss of dynorphin-mediated inhibition of voltage-dependent Ca2+ currents in hippocampal granule cells isolated from epilepsy patients is associated with mossy fiber sprouting. Neuroscience, 94: 465-471. (pdf)

Lie, A.A., Blümcke, I., Volsen, S.G., Wiestler, O.D., Elger, C.E., Beck, H. (1999) Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy. Neuroscience, 93: 449-456. (pdf)

Grunwald, T., Beck, H., Lehnertz, K., Blümcke, I., Pezer, N., Kutas, M., Kurthen, M., Karakas, H.M., Van Roost, D., Wiestler, O.D., Elger, C.E. (1999) Limbic P300s in temporal lobe epilepsy with and without Ammon’s horn sclerosis. Eur. J. Neurosci., 11: 1899-1906. (PubMed)

Lie, A.A., Blümcke, I., Beck, H., Wiestler, O.D., Elger, C.E., Schoen, S.W. (1999) 5′-Nucleotidase activity indicates sites of synaptic plasticity and reactive synaptogenesis in the human brain. J. Neuropathol. Exp. Neurol., 58: 451-458. (PubMed)

Becker, A.J., Gillardon, F., Blümcke, I., Langendörfer, D., Beck, H., Wiestler, O.D. (1999) Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus. Brain Res. Mol. Brain Res., 67:172-176. (PubMed)

Reckziegel, G., Beck, H., Schramm, J., Urban, B.W., Elger, C.E. (1999) Carbamazepine effects on Na+ currents in human dentate granule cells from epileptogenic tissue. Epilepsia, 40: 401-407. (PubMed)

Kunz, W.S., Goussakov, I.V., Beck, H., Elger, C.E. (1999) Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats. Brain Res., 826: 236-242. (pdf)

Blümcke, I., Beck, H., Suter, B., Hoffmann, D., Födisch, H.J., Wolf, H.K., Schramm, J., Elger, C.E., Wiestler, O.D. (1999) An increase of hippocampal calretinin-immunoreactive neurons correlates with early febrile seizures in temporal lobe epilepsy. Acta Neuropathol., 97: 31-39. (pdf)

Beck, H., Steffens, R., Heinemann, U., Elger, C.E. (1999) Ca2+-dependent inactivation of high-threshold Ca2+ currents in hippocampal granule cells of patients with chronic temporal lobe epilepsy. J. Neurophysiol., 82: 946-954. (PubMed)


Lie, A.A., Blümcke, I., Beck, H., Schramm, J., Wiestler, O.D., Elger, C.E. (1998) Altered patterns of Ca2+/calmodulin-dependent protein kinase II and calcineurin immunoreactivity in the hippocampus of patients with temporal lobe epilepsy. J. Neuropathol. Exp. Neurol., 57: 1078-1088. (PubMed)

Beck, H., Steffens, R., Elger, C.E., Heinemann, U. (1998) Voltage-dependent Ca2+ currents in epilepsy. Epilepsy Res., 32: 321-332. (pdf)

Schumacher, T.B., Beck, H., Steinhäuser, C., Schramm, J., Elger, C.E. (1998) Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy. Epilepsia, 39: 355-363. (PubMed)

Reckziegel, G., Beck, H., Schramm, J., Elger, C.E., Urban, B.W. (1998) Electrophysiological characterization of Na+ currents in acutely isolated human hippocampal dentate granule cells. J. Physiol., 509: 139-150. (PubMed)


Dietrich, D., Beck, H., Kral, T., Clusmann, H., Elger, C.E., Schramm, J. (1997) Metabotropic glutamate receptors modulate synaptic transmission in the perforant path: pharmacology and localization of two distinct receptors. Brain Res., 767: 220-227. (pdf)

Scheffler, B., Faissner, A., Beck, H., Behle, K., Wolf, H.K., Wiestler, O.D., Blümcke, I. (1997) Hippocampal loss of tenascin boundaries in Ammon’s horn sclerosis. Glia, 19: 35-46. (PubMed)

Beck, H., Steffens, R., Heinemann, U., Elger, C.E. (1997) Properties of voltage-activated Ca2+ currents in acutely isolated human hippocampal granule cells. J. Neurophysiol., 77: 1526-1537. (PubMed)

Beck, H., Clusmann, H., Kral, T., Schramm, J., Heinemann, U., Elger, C.E. (1997) Potassium currents in acutely isolated human hippocampal dentate granule cells. J. Physiol., 498: 73-85. (PubMed)


Blümcke, I., Beck, H., Scheffler, B., Hof, P.R., Morrison, J.H., Wolf, H.K., Schramm, J., Elger, C.E., Wiestler, O.D. (1996) Altered distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-D-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy. Acta Neuropathol., 92: 576-587. (pdf)

Blümcke, I., Beck, H., Nitsch, R., Eickhoff, C., Scheffler, B., Celio, M.R., Schramm, J., Elger, C.E., Wolf, H.K., Wiestler, O.D. (1996) Preservation of calretinin-immunoreactive neurons in the hippocampus of epilepsy patients with Ammon’s horn sclerosis. J. Neuropathol. Exp. Neurol., 55: 329-341. (PubMed)

Beck, H., Blümcke, I., Kral, T., Clusmann, H., Schramm, J., Wiestler, O.D., Heinemann, U., Elger, C.E. (1996) Properties of a delayed rectifier potassium current in dentate granule cells isolated from the hippocampus of patients with chronic temporal lobe epilepsy. Epilepsia, 37: 892-901. (PubMed)


Spenger, C., Beck, H., Studer, L., Evtouchenko, L., Seiler, W. (1995) Transplantation fötalen mesenzephalen Gewebes. Therapiewoche Schweiz, 11: 80-84.


Heinemann, U., Albrecht, D., Beck, H., Ficker, E., Nixdorf, B., Stabel, J., von Haebler, D. (1993) Potassium homeostasis and epileptogenesis in the immature hippocampus. In: Epileptogenic and excitotoxic mechanisms. Eds. Avanzini, G., Fariello, R., Heinemann, U., Mutani., R. London: John Libbey, pp. 99-106.


Wieser, H.G., Beck, H. (1992) Improvement of medically refractory temporal lobe complex partial epilepsy with dextromethorphan. J. Epilepsy, 5: 246-247.

Beck, H., Ficker, E., Heinemann, U. (1992) Properties of two voltage-activated potassium currents in acutely isolated juvenile rat dentate gyrus granule cells. J. Neurophysiol., 68: 2086-2099. (PubMed)

Heinemann, U., Beck, H., Dreier, J.P., Ficker, E., Stabel, J., Zhang, C.L. (1992) The dentate gyrus as a regulated gate for propagation of epileptiform activity. In: The dentate gyrus and its role in seizures. Eds. Ribak, C.E., Gall, C.M., Mody, I. Epilepsy Res. Suppl., 7: 273-280. (PubMed)

Heinemann, U., Albrecht, D., Beck, H., Ficker, E., von Haebler, D., Stabel, J. (1992) Delayed K+ regulation and K+ current maturation as factors of enhanced epileptogenicity during ontogenesis of the hippocampus of rats. In: Molecular Neurobiology of Epilepsy. Eds. Engel Jr, J., Wasterlain, C., Cavalheiro, E.A., Heinemann, U., Avanzini, G. Epilepsy Res. Suppl., 9: 107-114. (PubMed)

Heinemann, U., Beck, H., Draguhn, A. (in press) Antiepileptic Drugs. Neuropharmacology, xx: xx-xx.